Long-term lead elimination from plasma and whole blood after poisoning
نویسندگان
چکیده
OBJECTIVE Blood lead (B-Pb), one of the most used toxicological biomarker all kind, has serious limitations. Thus, the objective is to evaluate whether plasma lead (P-Pb) is more adequate. METHODS A long-term follow-up study of five cases of lead poisoning. P-Pb was analysed by inductively coupled plasma mass spectrometry. Kinetics after end of exposure was modelled. RESULTS P-Pb at severe poisoning was about 20 μg/L; haematological effects at about 5 μg/L. Biological half-time of P-Pb was about 1 month; B-Pb decay was much slower. CONCLUSION P-Pb is a valuable biomarker of exposure to and risk, particularly at high exposure.
منابع مشابه
Response to the letter to the editor entitled “Regarding long-term lead elimination from plasma and whole blood after poisoning”
Ad (1): All Wve cases had serum creatinine concentrations within the reference limits of our laboratory. Determination of blood urea nitrogen is not a clinical routine in our department. As regards serum transferases, case No. 3 had a slight, transient rise initially [aspartate aminotransferase: 0.88 (upper reference limit 0.60) kat/L; alanine aminotransferase: 1.1 (0.75) kat/L)], while all the...
متن کاملEffects of lead nitrate on histo-cytological alterations of corpuscles of Stannius of stinging catfish, Heteropneustes fossilis
Background: The present study investigated the effects of lead nitrate on the histo-cytological changes in the corpuscles of Stannius (CS) of Heteropneustes fossilis. Methods: Catfish, Heteropneustes fossilis were subjected to 657.6 mg/L and 164.4 mg/L of lead nitrate for 96 h and 28 days, respectively. Blood from fish was collected on 24, 48, 72 and 96 h in short-term and after 7, 14, 21, an...
متن کاملMetabolism of meso-2,3-dimercaptosuccinic acid in lead-poisoned children and normal adults.
Meso-2,3-dimercaptosuccinic acid (DMSA, or succimer) is an oral chelating agent for heavy-metal poisoning. While studying the urinary elimination of unaltered DMSA, altered DMSA (i.e., its mixed disulfides), and lead in children with lead poisoning, we observed a pattern of urinary drug elimination after meals suggestive of enterohepatic circulation. The excretion of lead in urine patterned the...
متن کاملتأثیر عصاره گشنیز بر میزان دفع سرب در کودکان 3 تا 7 ساله
Background and Aim: Lead (Pb) poisoning is the most common occupational poisoning that may affect family members of lead workers specially their children. The most important and irreversible effect of lead poisoning in children is on the developing of central nervous system and its evolution. High cost and severe side effects of chelating agents may result in incomplete treatment of lead poison...
متن کاملLong-term Follow-up Study of Pulmonary Function Test in Children with History of Hydrocarbon Aspiration
Background Aspiration of hydrocarbons causes several acute and chronic pulmonary complications; it may even lead to death. The aim of this study was to investigate the types of long-term pulmonary complications in children with a history of hydrocarbon aspiration. Materials and Methods In this case-control study, 21 children ...
متن کامل